Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset

Diabetes like many diseases and biological processes is not mono-causal. On the one hand multifactorial studies with complex experimental design are required for its comprehensive analysis. On the other hand, the data from these studies often include a substantial amount of redundancy such as proteins that are typically represented by a multitude of peptides. Coping simultaneously with both complexities (experimental and technological) makes data analysis a challenge for Bioinformatics

Impaired leptin activity in New Zealand Obese mice: model of angiogenesis

Leptin is prompt to drive angiogenesis, effecting proper vascularisation. Tissue remodeling (including adipose organ) is associated with the angiogenic response. The aim of this study was to investigate the effect of hyperleptinemia on angiogenesis in subcutaneous (s.c.) in vivo matrigel model in mice on a high fat (HF) diet. HF promoted adipose tissue accumulation and biochemical changes resembling metabolic syndrome. However, the impact of this dietary treatment on angiogenesis, measured in s.c. matrigel model was not significant. Changes in leptin concentration were not accompanied by significant angiogenic response. This lack of leptin activity and impaired signal transduction at the molecular level suggests malfunction of the leptin receptor in NZO mice

Auxin regulation of embryo development

Important steps in plant development are made shortly after fertilization. In a brief succession of cell divisions, the zygote is transformed into an embryo, a multicellular structure carrying all fundamental tissue types and the meristems. Hence, embryogenesis offers excellent opportunities to dissect the molecular control and cellular mechanisms underlying plant development. In the past decades, forward and reverse genetics studies have revealed that the plant hormone auxin plays a central role in the establishment of pattern and polarity in the Arabidopsis embryo. Here, we review the roles that localized auxin biosynthesis, directional transport and cell type-specific response play in embryo development. We focus on the molecular mechanisms, as well as the feedbacks that connect these disparate levels of regulation. Finally, we discuss the potential for hormonal cross-talk in auxin-dependent control of the key events during the earliest, formative phase of plant life.</p

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

19 novembre 19431943/11/19 (A44,N15581)